科研之友
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摘要
A simple procedure is described for the determination of scopolamine by square-wave voltammetry using a cathodically pretreated boron-doped diamond electrode. Cyclic voltammetry studies indicate that the oxidation of scopolamine is irreversible at a peak potential of 1.59 V (vs. Ag/AgCl (3.0 mol L-1 KCl)) in a 0.50 mol L-1 sulfuric acid solution. Under optimized conditions, the analytical curve obtained was linear (r = 0.9996) for the scopolamine concentration range of 1.0 to 110 mu mol L-1, with a detection limit of 0.84 mu mol L-1. The method was successfully applied to the determination of scopolamine in pharmaceutical formulations with minimum sample preparation.
- 出版日期2014
