Amyloid beta Induces Adhesion of Erythrocytes to Endothelial Cells and Affects Endothelial Viability and Functionality

作者:Nakagawa Kiyotaka*; Kiko Takehiro; Kuriwada Satoko; Miyazawa Taiki; Kimura Fumiko; Miyazawa Teruo
来源:Bioscience Biotechnology and Biochemistry, 2011, 75(10): 2030-2033.
DOI:10.1271/bbb.110318

摘要

It has been suggested that amyloid beta-peptide (A beta) might mediate the adhesion of erythrocytes to the endothelium which could disrupt the properties of endothelial cells. We provide evidence here that A beta actually induced the binding of erythrocytes to endothelial cells and decreased endothelial viability, perhaps by the generation of oxidative and inflammatory stress. These changes are likely to contribute to the pathogenesis of Alzheimer's disease.

  • 出版日期2011-10