Application of Li-6 diffusion-ordered NMR spectroscopy (DOSY) to confirming the solution structure of n-butyllithium

作者：Li Weibin; Kagan Gerald; Hopson Russell; Williard Paul G^*

来源：ARKIVOC, 2011, 180-187.

• Structure analysis
• DOSY
• NMR
• lithium
• solution state
• diffusion

The utility of recently introduced Li-6 diffusion-ordered NMR spectroscopy (DOSY) is demonstrated. Li-6 DOSY results can be correlated to H-1 data through 2-D Li-6{H-1} heteronuclear Overhauser effect NMR spectroscopy (HOESY) experiments. Li-6 DOSY quickly confirms H-1 DOSY results and allows unambiguous assignment of resonances to specific aggregates. Well known aggregates of lithium-6 n-butyllithium (n-(BuLi)-Li-6) are examined in deuterated tetrahydrofuran (THF-d(8)) solution as an example, and to reaffirm the previous literature conclusions about these complexes.

• 出版日期2011