Notch signaling: direct or what?

作者:Weinmaster G*
来源:Current Opinion in Genetics & Development, 1998, 8(4): 436-442.
DOI:10.1016/S0959-437X(98)80115-9

摘要

Notch signaling has been implicated in a wide variety of processes from cell-fate decisions, tissue patterning and morphogenesis to human diseases and cancer. A model for Notch directly regulating gene expression has been proposed and at least two signaling pathways have been identified; however, the molecular mechanism(s) by which Notch signaling produces so many outcomes remains unclear.

  • 出版日期1998-8