Association of rs11190870 near LBX1 with adolescent idiopathic scoliosis in East Asians: a systematic review and meta-analysis

作者：Chen Suzan^*; Zhao Linlu; Roffey Darren M; Phan Philippe; Wai Eugene K

来源：Spine Journal, 2014, 14(12): 2968-2975.

DOI：10.1016/j.spinee.2014.05.019

• Adolescent idiopathic scoliosis
• Etiology
• Genetic association study
• LBX1
• Ladybird homeobox 1
• rs11190870
• Single nucleotide polymorphism

BACKGROUND CONTEXT: The rs11190870 single nucleotide polymorphism in the 3%26apos;-flanking region of the LBX1 gene has been implicated in the etiology of adolescent idiopathic scoliosis (AIS). A thorough appraisal of the evidence supporting this association has not been previously attempted. %26lt;br%26gt;PURPOSE: To provide a comprehensive assessment and synthesis of the currently available evidence on the association between rs11190870 and AIS. %26lt;br%26gt;STUDY DESIGN: A systematic review and meta-analysis. %26lt;br%26gt;METHODS: This review followed the Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines. PubMed (MEDLINE), EMBASE, Scopus, and HuGE Literature Finder databases were systematically searched through November 2013 to identify relevant studies following a sensitive strategy. Summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using the fixed-effect inverse variance model for allelic (T vs. C) and genotypic comparisons. %26lt;br%26gt;RESULTS: Meta-analysis of four studies conducted in East Asian populations (n=3,215 AIS cases and n=15,347 controls) found a highly statistically significant and robust association between rs11190870 and AIS. Comparison of summary ORs indicated a codominant model effect of the T allele. Carriers of the TC and TT genotypes were 69% (OR=1.69, 95% CI: 1.48-1.94, p%26lt;.001) and 162% (OR=2.62, 95% CI: 2.28-3.02, p%26lt;.001), respectively, more likely to have AIS compared with carriers of the CC genotype. %26lt;br%26gt;CONCLUSIONS: Based on a comprehensive analysis of the currently available evidence, rs11190870 is likely a susceptibility variant for AIS in East Asians. Further investigation of this association is necessary in other populations.

• 出版日期2014-12