科研之友
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摘要
A new indole alkaloid, nauclofficine (1), together with three known alkaloids, naucleamide A (2), naucleamide D (3) and latifoliamide A (4), were isolated from the stems and leaves of Nauclea officinalis. Their structures were established on the basis of extensive spectral analyses. All known compounds were isolated from N. officinalis for the first time. The cytotoxicities of compounds 1 similar to 4 were evaluated against five cancer cell lines (HL-60, A549, SMMC-7721, MCF-7 and SW480). Research results showed that compounds 14 exhibited significant inhibitory effects with IC50 values comparable to those of cisplatin.
