Monitoring exposure to polycyclic aromatic hydrocarbons in an Australian population using pooled urine samples

作者：Thai Phong K^*; Heffernan Amy L; Toms Leisa Maree L; Li Zheng; Calafat Antonia M; Hobson Peter; Broomhall Sara; Mueller Jochen F

来源：Environment International, 2016, 88: 30-35.

DOI：10.1016/j.envint.2015.11.019

• OH-PAHs
• Urinary metabolite
• Biomonitoring
• Infant
• Exposure monitoring

Integrated exposure to polycyclic aromatic hydrocarbons (PAHs) can be assessed through monitoring of urinary mono-hydroxylated PAHs (OH-PAHs). The aim of this study was to provide the first assessment of exposure to PAHs in a large sample of the population in Queensland, Australia including exposure to infant (0-4 years). De-identified urine specimens, obtained from a pathology laboratory, were stratified by age and sex, and pooled (n = 24 pools of 100) and OH-PAHs were measured by gas chromatography-isotope dilution-tandem mass spectrometry. Geometric mean (GM) concentrations ranged from 30 ng/L (4-hydroxyphenanthrene) to 9221 ng/L (1-naphthol). GM of 1-hydroxypyrene, the most commonly used PAH exposure biomarker, was 142 ng/L. The concentrations of OH-PAHs found in this study are consistent with those in developed countries and lower than those in developing countries. We observed no association between sex and OH-PAH concentrations. However, we observed lower urinary concentrations of all OH-PAHs in samples from infants (0-4 years), children (5-14 years) and the elderly (>60 year old) compared with samples from other age groups (15-29, 30-44 and 45-59 years) which may be attributed to age-dependent behaviour-specific exposure sources.

• 出版日期2016-3