Direct alpha-Functionalization of Simple Aldehydes via Oxidative N-Heterocyclic Carbene Catalysis

作者：Mo Junming; Yang Ruojie; Chen Xingkuan; Tiwari Bhoopendra; Chi Yonggui Robin^*

来源：Organic Letters, 2013, 15(1): 50-53.

DOI：10.1021/ol303035r

A direct alpha-functionalization of simple aldehydes under N-Heterocyclic Carbene (NHC) catalysis and direct generation of ester enolate equivalents from nonfunctionalized aldehydes are disclosed. The catalysis involves selective enolate generation from an oxidatively generated NHC-bounded ester intermediate as a key step. The ester enolate intermediates undergo stereoselective reactions with enones and trifluoromethyl ketones.

• 出版日期2013-1-4
• 单位南阳理工学院