Antioxidant, anti-inflammatory and anticarcinogenic activities of edible red oak (Quercus spp.) infusions in rat colon carcinogenesis induced by 1,2-dimethylhydrazine

作者：Rocio Moreno Jimenez Martha; Trujillo Esquivel Fatima; Gallegos Corona Marco A; Reynoso Camacho Rosalia; Francisco Gonzalez Laredo Ruben; Alberto Gallegos Infante Jose; Elizabeth Rocha Guzman Nuria; Ramos Gomez Minerva^*

来源：Food and Chemical Toxicology, 2015, 80: 144-153.

DOI：10.1016/j.fct.2015.03.011

• Quercus sideroxyla
• Anticarcinogenic activity
• Anti-inflammatory
• Colon cancer
• Herbal infusions
• Polyphenols

Red oak (Quercus spp.) leaves are traditionally used as food in Mexico, and some of their infusions have potential anticarcinogenic and anti-inflammatory effects; however, these properties have not yet been scientifically tested. The aim of this work was to explore the anti-inflammatory activity in HT-29 cells and anticarcinogenic effect in 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis of red oak infusions. Quercus infusions were prepared and administered as the sole source of drink to male Sprague-Dawley rats (1% w/v) for the entire 26-week experimental period. On week 4, rats received 8 subcutaneous injections of DMH (21 mg/kg body weight) once a week. The results showed that mean tumor (0.9 +/- 0.2 vs. 2.6 +/- 0.3) and multiplicity (1.2 +/- 0.1 vs. 2.0 +/- 0.23), and beta-catenin protein level (2.2-fold) in adenocarcinomas were significantly lower in Quercus sideroxyla-treated group compared with DMH group. By contrast, Quercus durifolia and Quercus eduardii infusions had no protective effect. Additionally, the experiments in HT-29 cells confirmed that Q. sideroxyla infusion effectively decreased the levels of the inflammatory markers COX-2 and IL-8 by modulating the expression of NF-kappa B. These results highlight some of the molecular mechanisms related to the chemopreventive effect of Q. sideroxyla infusion and its potential value as a source of bioactive compounds.

• 出版日期2015-6