Ultrastructural and hormonal modulations of the thyroid gland following arecoline treatment in albino mice

作者：Dasgupta Romi; Chatterji Urmi; Nag T C; Chaudhuri Sengupta Santasri; Nag Debabrata; Maiti B R^*

来源：Molecular and Cellular Endocrinology, 2010, 319(1-2): 1-7.

DOI：10.1016/j.mce.2010.01.005

• Thyroid
• Arecoline
• Atropine
• Mice

Arecoline is a plant alkaloid of betel nut Areca catechu Arecoline has immunosuppressive, hepatotoxic, mutagenic and teratogenic effects, and disturbs some endocrine organs in rats The objective is to investigate the untoward effects of arecoline on the thyroid gland in mice Intraperitoneal injection of arecoline (10 mg/kg body weight only once) increased the serum T(3) and T(4) levels and decreased the serum TSH 20, 40 or 60 min after the treatment, with maximum effect at 40 min Chronic arecoline treatment (10 mg/kg body weight daily for 15 days) caused light microscopic and ultrastructural degenerations of thyrofollicular cells with depletion of T(3) and T(4) levels followed by the elevation of the TSH level. Atropine (arecoline antagonist) injection prevented the changes (hyperactivity) induced by acute (40 min) arecline treatment. Arecoline initially stimulates thyroid activity, and eventually inhibits the activity, atropine prevents thyroid dysfunction induced by arecoline.

• 出版日期2010-5-5
• 单位河北医科大学