An Elevated Level of Physical Activity Is Associated With Normal Lipoprotein(a) Levels in Individuals From Maracaibo, Venezuela

作者：Bermudez Valmore^*; Aparicio Daniel; Rojas Edward; Penaranda Lianny; Finol Freddy; Acosta Luis; Mengual Edgardo; Rojas Joselyn; Arraiz Nailet; Toledo Alexandra; Colmenares Carlos; Urribari Jesica; Sanchez Wireynis; Pineda Carlos; Rodriguez Dalia; Faria Judith; Anez Roberto; Cano Raquel; Cano Climaco; Sorell Luis; Velasco Manuel

来源：American Journal of Therapeutics, 2010, 17(3): 341-350.

DOI：10.1097/MJT.0b013e3181c1236e

• physical activity
• lipoprotein(a)
• lifestyle
• cardiovascular risk

Coronary artery disease is the main cause of death worldwide. Lipoprotein(a) [Lp(a)], is an independent risk factor for coronary artery disease in which concentrations are genetically regulated. Contradictory results have been published about physical activity influence on Lp(a) concentration. This research aimed to determine associations between different physical activity levels and Lp(a) concentration. A descriptive and cross-sectional study was made in 1340 randomly selected subjects (males = 598; females = 712) to whom a complete clinical history, the International Physical Activity Questionnaire, and Lp(a) level determination were made. Statistical analysis was carried out to assess qualitative variables relationship by chi(2) and differences between means by one-way analysis of variance considering a P value <0.05 as statistically significant. Results are shown as absolute frequencies, percentages, and mean +/- standard deviation according to case. Physical activity levels were ordinal classified as follows: low activity with 24.3% (n = 318), moderate activity with 35.0% (n = 458), and high physical activity with 40.8% (n = 534). Lp(a) concentration in the studied sample was 26.28 +/- 12.64 (IC: 25.59-26.96) mg/dL. Lp(a) concentration according to low, moderate, and high physical activity levels were 29.22 +/- 13.74, 26.27 +/- 12.91, and 24.53 +/- 11.35 mg/dL, respectively, observing statistically significant differences between low and moderate level (P = 0.004) and low and high level (P < 0.001). A strong association (chi(2) = 9.771; P = 0.002) was observed among a high physical activity level and a normal concentration of Lp(a) (less than 30 mg/dL). A lifestyle characterized by high physical activity is associated with normal Lp(a) levels.

• 出版日期2010-6