A diet high in alpha-linolenic acid and monounsaturated fatty acids attenuates hepatic steatosis and alters hepatic phospholipid fatty acid profile in diet-induced obese rats

作者：Hanke Danielle; Zahradka Peter; Mohankumar Suresh K; Clark Jaime L; Taylor Carla G^*

来源：Prostaglandins, Leukotrienes and Essential Fatty Acids, 2013, 89(6): 391-401.

DOI：10.1016/j.plefa.2013.09.009

• n-3 fatty acids
• alpha-linolenic acid
• MUFA
• Hepatic steatosis
• Diet-induced obese rats

This study investigated the efficacy of the plant-based n-3 fatty acid, alpha-linolenic acid (ALA), a dietary precursor of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), for modulating hepatic steatosis. Rats were fed high fat (55% energy) diets containing high oleic canola oil, canola oil, a canola/flax oil blend (C/F, 3:1), safflower oil, soybean oil, or lard. After 12 weeks, C/F and weight-matched (WM) groups had 20% less liver lipid. Body mass, liver weight, glucose and lipid metabolism, inflammation and molecular markers of fatty acid oxidation, synthesis, desaturation and elongation did not account for this effect. The C/F group had the highest total n-3 and EPA in hepatic phospholipids (PL), as well as one of the highest DHA and lowest arachidonic acid (n-6) concentrations. In conclusion, the C/F diet with the highest content of the plant-based n-3 ALA attenuated hepatic steatosis and altered the hepatic PL fatty acid profile.

• 出版日期2013-12