Stereoselective synthesis of a C1-C18 fragment of amphidinolides G and H

作者：Garcia Fortanet Jorge; Formentin Pilar; Diaz Oltra Santiago; Murga Juan; Carda Miguel^*; Alberto Marco J

来源：Tetrahedron, 2013, 69(15): 3192-3196.

DOI：10.1016/j.tet.2013.02.062

• Macrolides
• Amphidinolides
• Julia-Kocienski olefination
• Stille coupling
• Ohira-Bestmann reaction
• Alkyne silylstannation

A stereoselective synthesis of a C1-C18 segment of the structure of the cytotoxic macrolides amphidinolides G and H is reported. The target compound was retrosynthetically disconnected into three fragments. In the synthetic sense, connection of the fragments was made by means of a Stille coupling and a Julia-Kocienski olefination. Precursors from the chiral pool were used as the starting materials.

• 出版日期2013-4-15