Antibiotic Resistance and Substrate Profiles of the Class A Carbapenemase KPC-6

作者：Lamoureaux Toni L; Frase Hilary; Antunes Nuno T; Vakulenko Sergei B^*

来源：Antimicrobial Agents and Chemotherapy, 2012, 56(11): 6006-6008.

DOI：10.1128/AAC.01338-12

The class A carbapenemase KPC-6 produces resistance to a broad range of beta-lactam antibiotics. This enzyme hydrolyzes penicillins, the monobactam aztreonam, and carbapenems with similar catalytic efficiencies, ranging from 10(5) to 10(6) M-1 s(-1). The catalytic efficiencies of KPC-6 against cephems vary to a greater extent, ranging from 10(3) M-1 s(-1) for the cephamycin cefoxitin and the extended-spectrum cephalosporin ceftazidime to 10(5) to 10(6) M-1 s(-1) for the narrow-spectrum and some of the extended-spectrum cephalosporins.

• 出版日期2012-11