科研之友
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摘要
Following the identification of bone marrow multipotent cells that could adhere to plastic and differentiate along numerous mesenchymal lineages in vitro, a considerable effort has been invested in characterizing and expanding these cells, which are flow called "mesenchymal stem cells" (MSCS), in vitro. Over the years, numerous lines of evidence have been provided in support of their plasticity, their extraordinary immunomodulatory properties, their potential use for tissue engineering purposes, as Well as their ability to be recruited 10 sites of injury, where they might contribute a "natural in Vivo system for tissue repair." Moreover, some studies have attempted the characterization of their cell-surface Specific antigens and of their anatomical location in vivo. Lastly, it has been shown that similar Cells could be also isolated Front organs other than the hone marrow. Despite this impressive body of investigations, numerous questions related to file developmental Origin of these cells, their proposed pluripotency, and their role in bone modeling and remodeling and tissue repair in vivo are still largely unanswered. In addition, both a systematic phenotypic in vivo characterization of the MSC population and file development of a reproducible and faithful in vivo assay that Would test the ability of MSCS to self-renew, proliferate, and differentiate in vivo arc just beginning. This brief review summarizes the current knowledge in the field of study of MSCs and file outstanding questions. J. Cell. Biochem. 109: 277-282, 2010.
- 出版日期2010-2-1
