A Concise Synthesis of Tetrabenazine: An Intramolecular Aza-Prins-Type Cyclization via Oxidative C-H Activation

作者:Son Young Wook; Kwon Tae Hui; Lee Jae Kyun; Rae Ae Nim; Lee Jae Yeol; Cho Yong Seo*; Min Sun Joon
来源:Organic Letters, 2011, 13(24): 6500-6503.
DOI:10.1021/ol202792q

摘要

A concise synthesis of tetrabenazine and dihydrotetrabenazine is described. The key feature of this synthesis is the intramolecular aza-Prins-type cyclization of an amino allylsilane via oxidative C-H activation.

  • 出版日期2011-12-16