A potential role for zinc alterations in the pathogenesis of Alzheimer%26apos;s disease

作者：Lyubartseva Ganna^*; Lovell Mark A

来源：Biofactors, 2012, 38(2): 98-106.

DOI：10.1002/biof.199

• Alzheimer%26apos
• s disease
• amyloid beta peptide
• preclinical Alzheimer%26apos
• s disease
• zinc
• zinc transporter proteins
• mild clinical impairment

Alzheimer%26apos;s disease (AD), one of the major causes of disability and mortality in Western societies, is a progressive age-related neurodegenerative disorder. Increasing evidence suggests that the etiology of AD may involve disruptions of zinc (Zn) homeostasis. This review discusses current evidence supporting a potential role of Zn and zinc transporters (ZnTs) in processing of the amyloid beta protein precursor (APP) and amyloid beta (A beta) peptide generation and aggregation.

• 出版日期2012-4