Activin A maintains cerebral cortex neuronal survival and increases voltage-gated Na+ neuronal current

作者：Ge, Jingyan; Wang, Yinan; Liu, Haiyan; Chen, Fangfang; Cui, Xueling; Liu, Zhonghui^*

来源：Neural Regeneration Research, 2010, 5(19): 1464-1469.

DOI：10.3969/j.issn.1673-5374.2010.19.004

• activin A cerebral cortex neuron
• voltage gated sodium current neuro 2a cell neural regeneration

Activin A which was first described in 1986 has been shown to maintain hippocampal neuronal survival Activin A increases intracellular free Ca2+ via L type Ca2+ channels Our previous study showed that activin A promotes neurite growth of dorsal root ganglia in embryonic chickens and inhibits nitric oxide secretion The present study demonstrated for the first time that activin A could maintain cerebral cortex neuronal survival in vitro for a long period and that activin A was shown to increase voltage gated Na+ current (I-Na) in Neuro 2a cells which was recorded by patch clamp technique The present study revealed a novel mechanism for activin A as well as the influence of activin A on neurons by regulating expressions of vasoactive intestine peptide and inducible nitric oxide synthase

• 出版日期2010-10-15
• 单位吉林大学