Antimetastatic effects of Eclipta prostrata extract on oral cancer cells

作者：Liao Miao Yu; Chuang Chun Yi; Hsieh Ming Ju; Chou Ying Erh; Lin Chiao Wen; Chen Wen Rong; Lai Chih Ting; Chen Mu Kuan^*; Yang Shun Fa^*

来源：Environmental Toxicology, 2018, 33(9): 923-930.

DOI：10.1002/tox.22577

• Eclipta prostrata
• migration
• MMP-2
• oral cancer

Eclipta prostrata, a traditional Chinese medication, has been used for the treatment of several diseases. However, the molecular mechanism underlying the effects of Eclipta prostrata extracts (EPE) on human oral cancer cell metastasis remains unclear. We thus examined the effects of EPE on metastasis promoting proteins in oral cancer. Our results revealed that the EPE attenuated SCC-9, HSC-3, and TW2.6 cell migration and invasiveness by reducing matrix metalloproteinase (MMP)-2 enzyme activities. In addition, Western blot analysis revealed that EPE significantly reduced the levels of phosphorylated extracellular signal-regulated kinase 1/2 (ERK 1/2) but not those of c-Jun N-terminal kinase (JNK) 1/2 and p38. In conclusion, we found that EPE could inhibit oral cancer metastasis through the inhibition of MMP-2 expression. Therefore, EPE may be used to prevent the metastasis of oral cancer, and has the potential to be applied to cancer treatment.

• 出版日期2018-9
• 单位河北医科大学