科研之友
微信
新浪微博
Facebook
分享链接
摘要
A water-soluble polysaccharide from Hyriopsis cumingii (HCp) was isolated by hot-water extraction and ethanol precipitation. We investigated the preliminary neuroprotective activity of HCp on cerebral ischemia/reperfusion (I/R)-induced rat brain tissue injury using the middle cerebral artery occlusion (MCAO) model. The structural analysis showed that the major component of HCp (HP-I) is an alpha-(1-->4)-D-glucan branched with a single alpha-D-glucose at C-6 every five residues on average and has a weight-average molecular weight of about 2.65 x 10(5). Pharmacological studies revealed that HCp improves and restores nerve function impairment, significantly increases brain tissue total superoxide dismutase activity, lowers malondialdehyde content effectively, and reduces brain levels of caspase-3 mRNA expression in a dose-effect manner, indicating that H. cumingii polysaccharide possesses significant neuroprotective effects.
