Antiproliferative effects of curcuphenol, a sesquiterpene phenol

作者：Rodrigo Gloria; Almanza Giovanna R; Cheng Yajun; Peng Jiangnan; Hamann Mark; Duan Rui Dong; Akesson Bjorn^*

来源：Fitoterapia, 2010, 81(7): 762-766.

DOI：10.1016/j.fitote.2010.04.001

• Curcuphenol
• Cell proliferation
• Apoptosis
• Caspase

Curcuphenol is a sesquiterpene isolated from sponges and plants having several significant biological activities. The present study explored its effect on cell proliferation and apoptosis in Caco-2 human colon cancer cells. It was demonstrated that curcuphenol in concentrations in the range of 29-116 mu g/ml inhibited cell proliferation and DNA replication and induced cell death in a dose-dependent manner. The induction of apoptosis was associated with a stimulation of the activity of caspase-3. The findings presented here suggest that curcuphenol has antiproliferative and pro-apoptotic properties.

• 出版日期2010-10