High mortality in cirrhotic patients following hemorrhagic stroke

作者：Hung Tsung Hsing; Hsieh Yu Hsi; Tseng Kuo Chih; Tseng Chih Wei; Lee Hsing Feng; Tsai Chih Chun; Tsai Chen Chi

来源：Journal of Clinical Neuroscience, 2015, 22(6): 995-997.

DOI：10.1016/j.jocn.2014.12.009

• Cirrhosis
• Epidemiology
• Hemorrhagic stroke
• Mortality
• Subarachnoid hemorrhage

The impact of hemorrhagic stroke (HS) on the mortality of cirrhotic patients is unknown. To evaluate the morality risk of HS in cirrhotic patients, we used the Taiwan National Health Insurance Database to evaluate cirrhotic patients with HS who were discharged between 1 January and 31 December 2007. In total, there were 321 cirrhotic patients with HS. We randomly selected 3210 cirrhotic patients without HS as a comparison group. The 30 and 90 day mortality rates were 29.6% and 43.0% in the HS group, and 9.1% and 17.7% in the comparison group, respectively (p < 0.001). After Cox proportional hazard regression model adjustment of patients' sex, age, and other comorbid disorders, the hazard ratio (HR) for 90 day mortality in the HS group was 3.89 (95% confidence interval [CI] 3.20-4.71, p < 0.001), compared to the comparison group. In the subgroup analysis, the HR for 90 day mortality in the subarachnoid hemorrhage and other HS groups were 7.93 (95% CI 5.23-12.0, p < 0.001) and 3.51 (95% CI 2.85-4.32, p < 0.001), respectively, compared to the comparison group. In conclusion, HS is associated with a very high 90 day mortality risk in cirrhotic patients, in whom subarachnoid hemorrhage can also increase the risk of mortality eight-fold.

• 出版日期2015-6