摘要
Three new holostan-type triterpene glycosides, arguside F (1), impatienside B (2), and pervicoside D (3), together with a known saponin, holothurin B (4) were isolated from the sea cucumber Holothuria (Microthele) axiloga H. L. Clark. On the basis of spectroscopic data and chemical reactions, the structures of the new compounds were elucidated. Compound 2 showed significant antifungal activities against six strains (1 <= MIC80 <= 4 mu g/mL). The stereochemistry of holothurin B (4) isolated from the title sea cucumber was also solved through X-ray diffraction analysis.
- 出版日期2009-5
- 单位中国人民解放军空军军医大学; 中国人民解放军第二军医大学; 南京大学; 第四军医大学; 医药生物技术国家重点实验室