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摘要
Aptamers are a new class of nucleic acid probes, which are ssDNA/RNA molecules selected to target a wide range of ions, molecules and even cells through SELEX ( systematic evolution of ligands by exponential enrichment) technique. This paper presents aptamers and traditional selection approaches; summarizes recent efforts in developing new aptamer selection strategies; reviews new approaches for biomedical analysis, disease biomarker discovery and target therapy. Finally, the potential of aptamers in biomedicine is also discussed.
