An efficient synthesis of benzodiazepine derivatives via a one-pot, three-component reaction accelerated by a chitosan-supported superparamagnetic iron oxide nanocomposite

作者：Maleki Ali^*; Kamalzare Maryam

来源：Tetrahedron Letters, 2014, 55(50): 6931-6934.

DOI：10.1016/j.tetlet.2014.10.120

• Multicomponent reactions
• Nanocomposite
• Chitosan
• Fe3O4
• Benzodiazepine

This work describes the catalytic ability of Fe3O4@chitosan as an environmentally benign and stable composite nanocatalyst for the synthesis of benzodiazepine derivatives starting from o-phenylenediamine, dimedone, and different aldehydes via a one-pot, three-component reaction at room temperature. High-to-excellent yields, easy work-up, reusability of the nanocatalyst, and non-toxicity are some of the advantages of this protocol.

• 出版日期2014-12-10