Angiographic complexity of coronary artery disease according to SYNTAX score and clinical outcomes after revascularisation with newer-generation drug-eluting stents: a substudy of the BIOSCIENCE trial

作者：Franzone Anna; Taniwaki Masanori; Rigamonti Fabio; Heg Dik; Piccolo Raffaele; Roffi Marco; Tuller David; Muller Olivier; Vuilliomenet Andre; Cook Stephane; Weilenmann Daniel; Kaiser Christoph; Jamshidi Peiman; Juni Peter; Windecker Stephan^*; Pilgrim Thomas

来源：Eurointervention, 2016, 12(5): E595-E604.

DOI：10.4244/EIJV12I5A99

• biodegradable polymer sirolimus-eluting stents
• coronary artery disease
• durable polymer everolimus-eluting stents
• SYNTAX score

Aims: We sought to assess the performance of drug-eluting stents combining an ultrathin cobalt-chromium platform with a biodegradable polymer across categories of increasing SYNTAX score (SS).
Methods and results: Patients included in the BIOSCIENCE trial and randomly allocated to treatment with biodegradable polymer sirolimus-eluting stents (BP-SES) or durable polymer everolimus-eluting stents (DP-EES) were categorised according to SS tertiles (low < 8, medium 8-15, high > 15). The primary endpoint, target lesion failure (TLF), was defined as a composite of cardiac death, target vessel myocardial infarction and clinically indicated target lesion revascularisation. The patient-oriented endpoint (POCE) included death, myocardial infarction, or any repeat revascularisation. The SS was available in 2,041 out of 2,119 patients (96.3%). At two-year follow-up, patients with an SS > 15 experienced higher rates of both TLF and POCE as compared to patients with medium and low SS (14.5% vs. 8.1% and vs. 5.9%, p< 0.001; 22.7% vs. 14.9% and vs. 12.4%; p< 0.001), respectively. Comparable rates of the composite endpoints were documented for both stent types in each category of SS.
Conclusions: Increasing lesion complexity as assessed by SS was associated with higher rates of TLF and POCE in a contemporary PCI population with minimal exclusion criteria. BP-SES and DP-EES showed comparable performance across the entire spectrum of CAD severity.

• 出版日期2016-8