Adipose tissue inflammation in diabetes and heart failure

作者：Shimizu Ippei; Yoshida Yohko; Katsuno Taro; Minamino Tohru^*

来源：Microbes and Infection, 2013, 15(1): 11-17.

DOI：10.1016/j.micinf.2012.10.012

• p53
• Inflammation
• Insulin
• Senescence

Adipose tissue inflammation induces systemic insulin resistance in persons with obesity and heart failure, and has a crucial role in the progression of these diseases. Chronic inflammatory processes share a common mechanism in which increased production of reactive oxygen species activates p53 and NF-kappa B signaling, leading to up-regulation of pro-inflammatory cytokine expression and impairment of glucose metabolism. Since inhibition of these processes could slow the progression of various diseases, targeting adipose inflammation has the potential to become a new therapeutic approach for diabetes and heart failure.

• 出版日期2013-1