No effect of 2008/09 seasonal influenza vaccination on the risk of pandemic H1N1 2009 influenza infection in England

作者：Pebody Richard^*; Andrews Nick; Waight Pauline; Malkani Rashmi; McCartney Christine; Ellis Joanna; Miller Elizabeth

来源：Vaccine, 2011, 29(14): 2613-2618.

DOI：10.1016/j.vaccine.2011.01.046

• Pandemic
• TIV effectiveness

This study reports effectiveness of trivalent influenza vaccine (TIV) against confirmed pandemic influenza infection in England using a retrospective test-negative case-control study. Cases and controls were frequency matched by age, swabbing-week and region. On univariable and multivariable analysis adjusted for underlying clinical risk factors, cases were no more or less likely than controls to be vaccinated with 2008-09 or 2007-08 season TIV. Adjusted vaccine effectiveness for the former was -6% (-43% to 22%). Vaccine effectiveness did not differ significantly by age-group or hospitalisation status. There was no evidence prior vaccination with TIV significantly altered subsequent risk of pandemic influenza H1N1 2009 infection.

• 出版日期2011-3-21