Droplet-based microextraction in the aqueous two-phase system

作者：Choi Young Hoon; Song Young Soo; Kim Do Hyun^*

来源：Journal of Chromatography A, 2010, 1217(24): 3723-3728.

DOI：10.1016/j.chroma.2010.04.015

• Microextraction
• Aqueous two-phase system (ATPS)
• Electrohydrodynamics
• Droplet

This report is about microfluidic extraction systems based on droplets of aqueous two-phase system. Mass transfer between continuous phase and dispersed droplet is demonstrated by microextraction of ruthenium red in a microfluidic device. Droplets are generated with electrohydrodynamic method in the same device. By comparing brightness in the digital image of a solution with known concentrations of ruthenium red and those of a droplet in the microextraction, ruthenium red concentration was measured along the microextraction channel, resulting in good agreement with a simple diffusion model. The maximum partition coefficient was 9.58 in the experiment with the 70-mm-long-channel microextractor. The method is usable for terminating microextraction by electrohydrodynamic manipulation of droplet movement direction. Droplets of different ruthenium red concentration, 0.12 and 0.24% (w/w) in this experiment, can be moved to desired place of microfluidic system for further reaction through respectively branched outlets. In this study droplet-based microextraction is demonstrated and the mass transport is numerically analyzed by solving the diffusion-dissolution model.

• 出版日期2010-6-11