Diastereoselective Construction of 7-Methylenebicyclo[3.2.1]oct-3-en-2-one Derivatives by Palladium-Catalyzed Cyclization of Propargylic Acetates with 2-Oxocyclohex-3-enecarboxylates

作者：Yoshida Masahiro^*; Sugimura Chiyuki; Shishido Kozo

来源：Organic Letters, 2011, 13(13): 3482-3485.

DOI：10.1021/ol201243u

The reaction of propargylic acetates with 2-oxocyclohex-3-enecarboxylates in the presence of a palladium catalyst is described. Substituted 7-methylenebicyclo[3.2.1]oct-3-en-2-ones were synthesized in a highly diastereoselective manner.

• 出版日期2011-7-1