Association of the insulin-like growth factor-1 single nucleotide polymorphisms rs35767, rs2288377, and rs5742612 with osteoporosis risk: A meta-analysis

作者：Chen Ying-Chun^*; Zhang Lin; Li Er-Nan; Ding Li-Xiang; Zhang Gen-Ai; Hou Yu; Yuan Wei

来源：Medicine, 2017, 96(51): e9231.

DOI：10.1097/MD.0000000000009231

• meta-analysis
• osteoporosis
• polymorphism

Background:Insulin-like growth factor-1 (IGF-1) plays an important role in the regulation of bone formation and mineralization. We aimed to perform a meta-analysis to assess the association of three IGF-1 single nucleotide polymorphisms (SNPs) rs35767, rs2288377, and rs5742612 with osteoporosis risk.Methods:A systematic search of PubMed, Web of Science, Embase, Medline, Scopus, CNKI, and Wanfang databases was conducted. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using a fixed effects model.Results:Four Chinese case-control studies with a total of 2807 participants were included in this meta-analysis. The results revealed an association between rs35767 and osteoporosis risk in all study subjects (women and men) in dominant (OR 1.32, 95% CI 1.13-1.53, P<.001), recessive (OR 1.73, 95% CI 1.35-2.21, P<.001), homozygote (OR 1.89, 95% CI 1.46-2.45, P<.001), and allelic (OR 1.31, 95% CI 1.18-1.47, P<.001) models. Subgroup analysis according to gender showed that rs35767 was associated with osteoporosis risk in women under dominant (OR 1.29, 95% CI 1.08-1.54, P=.005), recessive (OR 1.59, 95% CI 1.19-2.12, P=.002), homozygote (OR 1.73, 95% CI 1.28-2.34, P<.001), and allelic (OR 1.28, 95% CI 1.12-1.47, P<.001) models. Meta-analysis did not find associations of rs2288377 and rs5742612 with osteoporosis risk. There was no evidence of between-study heterogeneity and publication bias.Conclusion:Our results suggest that rs35767 is associated with osteoporosis risk in Chinese, whereas there is no association of rs2288377 and rs5742612 with osteoporosis risk.

• 出版日期2017-12
• 单位首都医科大学