Antidyslipidemic effect and antioxidant activity of anthraquinone derivatives from Rheum emodi rhizomes in dyslipidemic rats

作者：Mishra Sunil K; Tiwari Shashi; Shrivastava Atul; Srivastava Shishir; Boudh Goutam K; Chourasia Shivendra K; Chaturvedi Upma; Mir Snober S; Saxena Anil K; Bhatia Gitika; Lakshmi Vijai^*

来源：Journal of Natural Medicines, 2014, 68(2): 363-371.

DOI：10.1007/s11418-013-0810-z

• Rheum emodi rhizomes
• Lecithin-cholesterol acyl transferase activity
• Post heparin lipolytic activity
• HMG-CoA reductase
• Antidyslipidemic activity
• Antioxidant

The aim of the present study was to evaluate the antidyslipidemic effect of ethanolic extract of Rheum emodi rhizomes and its constituents in Triton-WR-1339 and high-fat diet (HFD)-induced dyslipidemic rats. In preliminary screening, the ethanolic extract showed significant activity in Triton-treated rats. Bioassay-guided fractionation of the ethanolic extract resulted in the identification of four anthraquinone derivatives, viz. chrysophanol, emodin, chrysophanol 8-O-beta-d-glucopyranoside and emodin 8-O-beta-d-glucopyranoside as active constituents. All these compounds significantly reduced plasma lipid levels. The most active compound emodin showed significant lipid-lowering activity in the HFD-fed model. In addition, these compounds showed significant antioxidant activity. The effect of emodin on enzymes modulating lipid metabolism confirms and supports the efficiency of emodin as a potent antidyslipidemic agent.

• 出版日期2014-4