Amelioration of Systemic Lupus Erythematosus by Withangulatin A in MRL/lpr Mice

作者：Sun, Lijuan; Zhou, Lin^*; Chen, Mingcang; Zhong, Renqian; Liu, Jianwen

来源：Journal of Cellular Biochemistry, 2011, 112(9): 2376-2382.

DOI：10.1002/jcb.23160

• WITHANGULATIN A
• SYSTEMIC LUPUS ERYTHEMATOSUS
• BAFF
• MRL/LPR MICE

We have previously reported the anti-inflammatory potential and the possible underlying mechanisms of Withangulatin A (WA), which is an active component isolated from Physalis angulata L. Here, we demonstrated that WA might improve the life quality, as well as reduced the accumulation of proteinuria symptoms and levels of anti-double-stranded DNA antibodies in MRL/lpr mice. Moreover, WA could improve renal histopathologic characteristics of MRL/lpr mice. Intriguingly, expression of B cell-activating factor (BAFF), BAFF-R and related gene in the spleen were significantly reduced in 10 mg/kg WA-treated mice compared with that in 5 mg/kg WA-treated mice and untreated mice. These findings indicate that WA might have a pleiotropic therapeutic effect through their immunosuppression via inhibiting BAFF signaling, which suggest a potential application of this active constituent in the treatment of SLE. J. Cell. Biochem. 112: 2376-2382, 2011.

• 出版日期2011-9
• 单位华东理工大学; 中国人民解放军第二军医大学; 湖北大学