科研之友
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摘要
The first multicomponent catalytic asymmetric synthesis of spiro-acetals has been described. Hybrid molecules comprising a spiro-acetal scaffold (a natural-product inspired scaffold) and an a-amino acid motif (a privileged fragment) are easily available through a gold phosphate-catalysed one-pot three component coupling reaction of alkynols, anilines and glyoxylic acid.
- 出版日期2013
