科研之友
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摘要
Matrix metalloproteinases have proteolytic activity and are implicated in the degradation of extracellular matrix in cartilage. Studies have revealed the distribution of MMP-7 in human osteoarthritic synovial membrane and shown increased expression of MMP8 in human osteoarthritic cartilage. To investigate the potential association of MMP-7 and MMP-8 polymorphisms with osteoarthritis susceptibility, Sequenom MassARRAY method was performed to determine the genotypes of 416 osteoarthritis cases and 495 controls. The associations between the investigated SNPs and osteoarthritis risk were assessed under multiple inheritance models and haplotype analysis by multivariate logistic regression analysis with and without adjustments for age and gender. We found a risk allele for osteoarthritis in cases such as the allele "T" of rs12285347 in the MMP-7 gene (OR = 1.23, 95% CI = 1.01-1.49, P = 0.036). When we analyzed the association under different inheritance models, we found MMP-7 rs12285347 was associated with increased risk of developing osteoarthritis in an additive model with adjustment by age and gender (adjusted OR = 1.43, 95% CI = 1.04-1.95, P = 0.03) or without (OR = 1.24, 95% CI = 1.02-1.51, P = 0.03) and in a dominant model (adjusted OR = 1.55, 95% CI = 1.01-2.37, P = 0.04). Furthermore, MMP-8 rs1892886 also correlated with increased risk of developing osteoarthritis in a recessive model (OR = 1.88, 95% CI = 1.07-3.31, P = 0.03). The present study provided evidence for a osteoarthritis susceptibility locus, MMP-7 rs12285347 and MMP8 rs1892886, in a Chinese Han population from Northwest China. However, a significant association with other ethnicities and functional significance of these polymorphisms needs further confirmation.
