Drug nanocrystals for the formulation of poorly soluble drugs and its application as a potential drug delivery system

作者：Gao Lei; Zhang Dianrui^*; Chen Minghui

来源：Journal of Nanoparticle Research, 2008, 10(5): 845-862.

DOI：10.1007/s11051-008-9357-4

• poorly soluble drugs
• nanocrystals
• bioavailability
• precipitation
• pearl milling
• high-pressure homogenization
• colloids
• nanomedicine

Formulation of poorly soluble drugs is a general intractable problem in pharmaceutical field, especially those compounds poorly soluble in both aqueous and organic media. It is difficult to resolve this problem using conventional formulation approaches, so many drugs are abandoned early in discovery. Nanocrystals, a new carrier-free colloidal drug delivery system with a particle size ranging from 100 to 1000 nm, is thought as a viable drug delivery strategy to develop the poorly soluble drugs, because of their simplicity in preparation and general applicability. In this article, the product techniques of the nanocrystals were reviewed and compared, the special features of drug nanocrystals were discussed. The researches on the application of the drug nanocrystals to various administration routes were described in detail. In addition, as introduced later, the nanocrystals could be easily scaled up, which was the prerequisite to the development of a delivery system as a market product.

• 出版日期2008-5
• 单位山东大学