Apparent diffusion coefficient for molecular subtyping of non-gadolinium-enhancing WHO grade II/III glioma: volumetric segmentation versus two-dimensional region of interest analysis

作者：Thust S C; Hassanein S; Bisdas S; Rees J H; Hyare H; Maynard J A; Brandner S; Tur C; Jager H R; Yousry T A; Mancini L

来源：European Radiology, 2018, 28(9): 3779-3788.

DOI：10.1007/s00330-018-5351-0

• Brain
• Diffusion magnetic resonance imaging
• Isocitrate dehydrogenase
• Glioma
• Neuroimaging

To investigate if quantitative apparent diffusion coefficient (ADC) measurements can predict genetic subtypes of non-gadolinium-enhancing gliomas, comparing whole tumour against single slice analysis.
Volumetric T2-derived masks of 44 gliomas were co-registered to ADC maps with ADC mean (ADC(mean)) calculated. For the slice analysis, two observers placed regions of interest in the largest tumour cross-section. The ratio (ADC(ratio)) between ADC(mean) in the tumour and normal appearing white matter was calculated for both methods.
Isocitrate dehydrogenase (IDH) wild-type gliomas showed the lowest ADC values throughout (p < 0.001). ADC(mean) in the IDH-mutant 1p19q intact group was significantly higher than in the IDH-mutant 1p19q co-deleted group (p < 0.01). A volumetric ADC(mean) threshold of 1201 x 10(-6) mm(2)/s identified IDH wild-type with a sensitivity of 83% and a specificity of 86%; a volumetric ADC(ratio) cut-off value of 1.65 provided a sensitivity of 80% and a specificity of 92% (area under the curve (AUC) 0.9-0.94). A slice ADC(ratio) threshold for observer 1 (observer 2) of 1.76 (1.83) provided a sensitivity of 80% (86%), specificity of 91% (100%) and AUC of 0.95 (0.96). The intraclass correlation coefficient was excellent (0.98).
ADC measurements can support the distinction of glioma subtypes. Volumetric and two-dimensional measurements yielded similar results in this study.
aEuro cent Diffusion-weighted MRI aids the identification of non-gadolinium-enhancing malignant gliomas
aEuro cent ADC measurements may permit non-gadolinium-enhancing glioma molecular subtyping
aEuro cent IDH wild-type gliomas have lower ADC values than IDH-mutant tumours
aEuro cent Single cross-section and volumetric ADC measurements yielded comparable results in this study.

• 出版日期2018-9