科研之友
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摘要
A practical, mild, and high-yielding synthetic approach for the synthesis of unknown tetrahydropyrimidinyl substituted 3-coumarins as hybrid scaffolds, potentially useful new chemical entities (NCEs), via metal- and catalyst-free multicomponent cyclization is described. The enhanced nucleophilicity of 3-amino coumarins versus 4-amino coumarin is explained via the difference in C-13 NMR values () of vinylic carbons. X-ray crystal analysis defines the structure of a representative set of example.
- 出版日期2016
