BACILLUS SUBTILIS-FERMENTED RED BEAN (RED BEAN NATTO) REDUCES HYPERLIPIDEMIA LEVELS IN HAMSTERS FED AN ATHEROGENIC DIET

作者：Lin Nai Nu; Lee Yen Feng; Chi Yi Jen; Wang Ming Fu; Chan Yin Ching; Chan Kung Chi; Chen Ying Ju; Chiu Yung Tsung^*

来源：Journal of Food Biochemistry, 2017, 41(1): UNSP e12264.

DOI：10.1111/jfbc.12264

The purpose of this study was to investigate the effects of 50% red beans ethanol natto extracts fermented by Bacillus subtilis on hyperlipidemia in hamsters. Forty male hamsters were randomly assigned to normal control, high-fat control, and high-fat with RBNE (red beans natto extracts) (200 and 1000 mg/kg BW) groups. RBNE treatment for 8 weeks significantly decreased the body and visceral fat weight in hamsters. Compared to the high-fat diet group, the plasma total cholesterol (TC), total triacylglycerol (TAG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and oxidized LDL (oxLDL) concentrations as well as atherogenic index of plasma AIP [Log(TAG/HDL-C)] were significantly lower in the RBNE-fed group. The consumption of RBNE significantly reduced the liver contents of TC, esterified cholesterol (CE) and alanine aminotransferase (ALT), and increased a regulator of lipid metabolism: peroxisome proliferator-activated receptor alpha (PPAR-alpha). Furthermore, the circulating level of irisin was decreased.

• 出版日期2017-2