Novel Hybrid Formulations Based on Thiourea Derivatives and Core@Shell Fe3O4@C-18 Nanostructures for the Development of Antifungal Strategies

作者：Limban Carmen; Missir Alexandru Vasile; Caproiu Miron Teodor; Grumezescu Alexandru Mihai; Chifiriuc Mariana Carmen^*; Bleotu Coralia; Marutescu Luminita; Papacocea Marius Toma; Nuta Diana Camelia

来源：Nanomaterials, 2018, 8(1): 47.

DOI：10.3390/nano8010047

• new thiourea derivatives
• Fe3O4@C-18 nanoparticles
• antifungal
• Candida albicans
• biofilm
• biocompatibility

The continuously increasing global impact of fungal infections is requiring the rapid development of novel antifungal agents. Due to their multiple pharmacological activities, thiourea derivatives represent privileged candidates for shaping new drugs. We report here the preparation, physico-chemical characterization and bioevaluation of hybrid nanosystems based on new 2-((4-chlorophenoxy)methyl)-N-(substituted phenylcarbamo-thioyl)benzamides and Fe3O4@C-18 core@shell nanoparticles. The new benzamides were prepared by an efficient method, then their structure was confirmed by spectral studies and elemental analysis and they were further loaded on Fe3O4@C-18 nanostructures. Both the obtained benzamides and the resulting hybrid nanosystems were tested for their efficiency against planktonic and adherent fungal cells, as well as for their in vitro biocompatibility, using mesenchymal cells. The antibiofilm activity of the obtained benzamides was dependent on the position and nature of substituents, demonstrating that structure modulation could be a very useful approach to enhance their antimicrobial properties. The hybrid nanosystems have shown an increased efficiency in preventing the development of Candida albicans (C. albicans) biofilms and moreover, they exhibited a good biocompatibility, suggesting that Fe3O4@C(18)core@shell nanoparticles could represent promising nanocarriers for antifungal substances, paving the way to the development of novel effective strategies with prophylactic and therapeutic value for fighting biofilm associated C. albicans infections.

• 出版日期2018-1