Atypical progressive multifocal leukoencephalopathy (PML) in a patient with pulmonary sarcoidosis

作者：Le Guilloux J^*; Roubiou C; Mallet J; Bouvry D; Alkhalil A; Coman I; Belin C; Gorochov G; Carpentier A; Mokhtari K; Carpentier A F

来源：Revue Neurologique, 2010, 166(3): 341-345.

DOI：10.1016/j.neurol.2009.05.015

• Progressive multifocal leukoencephalopathy
• Sarcoidosis
• Contrast enhancement
• Immunodepression
• JC virus

Introduction. - Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of central nervous system due to the JC virus. PML generally occurs in immunocompromised hosts and has a fatal outcome.
Observation. - We report a case of an atypical PML in a patient with pulmonary sarcoidosis: MRI showed multifocal and punctate contrast enhancements. The diagnostic was made by brain biopsy.
Conclusion. - The pathophysiology of this association is probably related to the immunodepression induced by sarcoidosis.

• 出版日期2010-3