Pediatric HIV: new opportunities to treat children

作者：Van der Linden Dimitri^*; Callens Steven; Brichard Benedicte; Colebunders Robert

来源：Expert Opinion on Pharmacotherapy, 2009, 10(11): 1783-1791.

DOI：10.1517/14656560903012377

• antiretroviral therapy
• HIV
• HIV DNA/RNA PCR
• infants
• pediatric HIV infection
• perinatal HIV infection

Background: Treating HIV-infected children remains a challenge due to a lack of treatment options, appropriate drug formulations and, in countries with limited resources, insufficient access to diagnostic tests and treatment. Objective: To summarize current data concerning new opportunities to improve the treatment of HIV-infected children. Methods: This review includes data from the most recently published peer-reviewed publications, guidelines or presentations at international meetings concerning new ways to treat HIV-infected children. Results/conclusions: New WHO guidelines recommend starting combination antiretroviral treatment in all infants aged < 1 year. Although this is common practice in some high-income countries, implementation of these recommendations in countries with limited resources is still a challenge. There is still an important gap between the availability of licensed drugs in children compared with adults. There remains a need for further pharmacokinetic studies, and for more pediatric formulations of antiretroviral drugs with improved palatability.

• 出版日期2009-8