Mellpaladines and dopargimine, novel neuroactive guanidine alkaloids from a Palauan Didemnidae tunicate

作者：Uchimasu Hajime; Matsumura Ken; Tsuda Masashi; Kumagai Keiko; Akakabe Mai; Fujita Masaki J; Sakai Ryuichi^*

来源：Tetrahedron, 2016, 72(45): 7185-7193.

DOI：10.1016/j.tet.2016.09.051

• Marine alkaloid
• Tunicate
• Neuronal receptor
• Polysulfur dopamine

Novel guanidine alkaloids dopargimine (1) and mellpaladines A-C (2-4) were isolated from a Palauan Didemnidae tunicate. The structures of 1-4 were elucidated on the basis of spectral data along with chemical reactions. A putative biosynthetic building block of 1-4, 4-guanidinobutyric acid (5), and dimeric polysulfur dopamine, as well as lissoclibadins 11 (6a) and 12 (6b) were also isolated. Compounds 1-3 bound to synaptic receptors, and modulated behavioral profiles of mice after intracerebroventricular injection.

• 出版日期2016-11-10