DETERMINATION OF 2-HYDROXYESTRONE/16 alpha-HYDROXYESTRONE RATIO IN URINE OF MEXICAN WOMEN AS A RISK INDICATOR FOR BREAST CANCER AND ITS RELATIONSHIP WITH OTHER RISK FACTORS

作者:Godinez Martinez Estela Ytelina; Santillan Ballesteros Rene; Lemus Bravo Ana Elena; Samano Reyna; Tolentino Dolores Maricruz; Rodriguez Ventura Ana Lilia; Juarez Gonzalez Ana Rosa
来源:Nutricion Hospitalaria, 2015, 31(2): 835-840.
DOI:10.3305/nh.2015.31.2.8172

摘要

The urinary ratio 2-hydroxyoestrone/16 alpha-hydroxyoestrone (URME), has been proposed in various populations on the world as a risk indicator for breast cancer (BC), however in the Mexican population has never been determined.
Objective: To determine URME Mexican women and establish its relationship with risk factors for BC.
Material and Methods: Cross-sectional study of 142 premenopausal and 42 posmenopausal women. The URME was determined with the kit ESTRAMET (TM) and was related to risk factors for BC. Correlations and linear regressions were performed.
Results: The median URME was 0.90 (RIQ 0.64-1.18). The body mass index (BMI) and early menarche contribute 5.4% of their variability (F=5.17; p<0.000). IMC participated in 6.1% of the variability of 2-hydroxyoestrone in premenopausal (F=4.40; p<0.000) and 18.1% in posmenopausal women (F=8.85; p<0.000).
Conclusion: The URME was approximate to 50% lower than reported for other populations and inversely proportional to BMI.

  • 出版日期2015-2

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