Analysis of omnoponum by surface-ionization mass spectrometry and liquid chromatography tandem mass spectrometry methods

作者：Usmanov Dilshadbek^*; Khasanov Usman; Pantsirev Aleksey; Van Bocxlaer Jan

来源：Journal of Pharmaceutical and Biomedical Analysis, 2010, 53(4): 1058-1062.

DOI：10.1016/j.jpba.2010.07.004

• Omnoponum
• Opium alkaloids
• Surface-ionization mass spectrometry
• HPLS/MS/MS

This paper provides the development of analytical capabilities of surface-ionization mass spectrometry (SI/MS) and high performance liquid chromatography with tandem mass spectrometry (HPLC/MS/MS) for narcotic analgesic omnoponum, which perfectly exemplifies a mixture of opium alkaloids. It has been revealed that the investigated opiates solution, omnoponum, is ionized by the surface ionization (SI) method with high sensitivity. In the SI mass spectrum, M(+), (M-H)(+), (M-H-2nH)(+), (M-R)(+) and (M-R-2nH)(+) ion lines, where M is a molecule, H is the hydrogen atom and R is a radical, were observed. These ion lines consist of combined omnoponum mixture SI mass spectra, i.e. morphine, codeine, thebaine, papaverine, and narcotine. Moreover, while the study of omnoponum by HPLC/MS/MS methods has attested that the mixture really consists of 5 components, it has been demonstrated that the SI/MS method can be utilized for the analysis of this mixture without the necessity of its chromatographic separation.

• 出版日期2010-12-1