Different aberrant expression pattern of immune checkpoint receptors in patients with PTCL and NK/T-CL

作者：Liao, Ziwei; Lv, Xuewen; Liu, Sichu; He, Zifan; Chen, Shaohua; Wang, Liang; Li, Wenyu; Li, Yangqiu^*

来源：Asia-Pacific Journal of Clinical Oncology, 2018, 14(5): e252-e258.

DOI：10.1111/ajco.12850

• BTLA
• CTLA-4
• LAG-3
• NK
• T-CL
• PD-1
• PTCL
• TIGIT
• TIM-3

AimTo better understand the T-cell immunodeficiency status in patients with peripheral T-cell lymphomas (PTCLs) and NK/T-cell lymphomas (NK/T-CLs), the T-cell inhibitory receptors expression pattern was investigated. @@@ MethodsThe expression levels of programmed death 1 (PD-1), cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), B/T lymphocyte attenuator (BTLA), lymphocyte-activation gene 3 (LAG-3), T-cell immunoglobulin-3 (TIM-3), T-cell immunoglobulin and ITIM domain (TIGIT) genes were detected in peripheral blood mononuclear cells (PBMCs) from patients and healthy volunteers by quantitative real-time-PCR, the correlation between different gene expression levels was analyzed. @@@ ResultsSignificantly higher expression of PD-1, CTLA-4, BTLA, LAG-3, TIM-3 and TIGIT can be observed as a common characteristic in patients with PTCL or NK/T-CL. However, the coexpression pattern seemed different between subtypes. Their overexpression is also related to disease progression stage. @@@ ConclusionWe first characterized the expression pattern of six T-cell inhibitory receptor genes in PTCL and NK/T-CL, which might work as immune biomarkers for evaluation the immunosuppression status and help to establish the precision targets of immunotherapy.

• 出版日期2018-10
• 单位暨南大学; 广东省人民医院