SORTING OF PROTEIN-A TO THE STAPHYLOCOCCAL CELL-WALL

作者：SCHNEEWIND O^*; MODEL P; FISCHETTI VA

来源：Cell, 1992, 70(2): 267-281.

DOI：10.1016/0092-8674(92)90101-H

The cell wall of gram-positive bacteria can be thought of as representing a unique cell compartment, which contains anchored surface proteins that require specific sorting signals. Some biologically important products are anchored in this way, including protein A and fibronectin binding protein of Staphylococcus aureus and streptococcal M protein. Studies of staphylococcal protein A and Escherichia coli alkaline phosphatase show that the signal both necessary and sufficient for cell wall anchoring consists of an LPXTGX motif, a C-terminal hydrophobic domain, and a charged tail. These sequence elements are conserved in many surface proteins from different gram-positive bacteria. We propose the existence of a hitherto undescribed sorting mechanism that positions proteins on the surface of gram-positive bacteria.

• 出版日期1992-7-24