Absence of a simple code: how transcription factors read the genome

作者：Slattery Matthew^*; Zhou Tianyin; Yang Lin; Machado Ana Carolina Dantas; Gordan Raluca; Rohs Remo

来源：TRENDS IN BIOCHEMICAL SCIENCES, 2014, 39(9): 381-399.

DOI：10.1016/j.tibs.2014.07.002

Transcription factors (TFs) influence cell fate by interpreting the regulatory DNA within a genome. TFs recognize DNA in a specific manner; the mechanisms underlying this specificity have been identified for many TFs based on 3D structures of protein DNA complexes. More recently, structural views have been complemented with data from high-throughput in vitro and in vivo explorations of the DNA-binding preferences of many TFs. Together, these approaches have greatly expanded our understanding of TF-DNA interactions. However, the mechanisms by which TFs select in vivo binding sites and alter gene expression remain unclear. Recent work has highlighted the many variables that influence TF-DNA binding, while demonstrating that a biophysical understanding of these many factors will be central to understanding TF-function.

• 出版日期2014-9