Maintenance Bevacizumab is Associated With Increased Hemoglobin in Patients With Advanced, Nonsquamous, Non-Small Cell Lung Cancer

作者：Riess Jonathan W^*; Logan Aaron C; Krupitskaya Yelena; Padda Sukhmani; Clement Duchene Christelle; Ganjoo Kristen; Colevas A Dimitrios; San Pedro Salcedo Melanie; Kuo Calvin J; Wakelee Heather A

来源：Cancer Investigation, 2012, 30(3): 231-235.

DOI：10.3109/07357907.2012.656862

• Angiogenesis
• Cancer biomarkers
• Non-small cell lung cancer
• Clinical trials
• VEGF

We retrospectively analyzed hematologic parameters in 22 patients with advanced, nonsquamous, NSCLC undergoing VEGF inhibition on a phase II clinical trial of bevacizumab, carboplatin, and gemcitabine. We also examined TTP in relation to hemoglobin changes. Median hemoglobin increased significantly from a 12.9 g/dL pretreatment to 13.8 g/dL (p = .01) after the second cycle of maintenance bevacizumab until the first off cycle measurement. There was no difference in TTP in patients who achieved a rise in hemoglobin compared with patients who did not (median 238 days vs. 268 days, p = .38.) Maintenance bevacizumab is associated with increased hemoglobin in advanced, nonsquamous, NSCLC patients.

• 出版日期2012-3