Abnormal Visual Activation in Parkinson's Disease Patients

作者：Cardoso Ellison Fernando^*; Fregni Felipe; Maia Fernanda Martins; Melo Luciano M; Sato Joao R; Cruz Antonio Cesario Jr; Bianchi Edno Tales; Fernandes Danilo Botelho; Ribeiro Monteiro Mario Luiz; Barbosa Egberto Reis; Amaro Edson Jr

来源：Movement Disorders, 2010, 25(11): 1590-1596.

DOI：10.1002/mds.23101

• Parkinson's disease
• hallucinations
• fMRI
• dopamine
• visual symptoms

Among nonmotor symptoms observed in Parkinson's disease (PD) dysfunction in the visual system, including hallucinations, has a significant impact in their quality of life. To further explore the visual system in PD patients we designed two fMRI experiments comparing 18 healthy volunteers with 16 PD patients without visual complaints in two visual fMRI paradigms: the flickering checkerboard task and a facial perception paradigm. PD patients displayed a decreased activity in the primary visual cortex (Broadmann area 17) bilaterally as compared to healthy volunteers during flickering checkerboard task and increased activity in fusiform gyms (Broadmann area 37) during facial perception paradigm. Our findings confirm the notion that PD patients show significant changes in the visual cortex system even before the visual symptoms are clinically evident. Further studies are necessary to evaluate the contribution of these abnormalities to the development visual symptoms in PD.

• 出版日期2010-8-15